Ciuffa, Rodolfo; Lamark, Trond; Tarafder, Abul K.; Guesdon, Audrey; Rybina, Sofia; Hagen, Wim J.H.; Johansen, Terje; Sachse, Carsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-05)
The scaffold protein p62/SQSTM1 is involved in protein
turnover and signaling and is commonly found in
dense protein bodies in eukaryotic cells. In autophagy,
p62 acts as a selective autophagy receptor
that recognizes and shuttles ubiquitinated proteins
to the autophagosome for degradation. The structural
organization of p62 in cellular bodies and the
interplay of these assemblies with ubiquitin ...